Anti-Glypican 3 Monoclonal Antibody (RMAB-0251401)
Cat. No.: RMAB-0251401
Category: Primary Antibodies
Research Area: Cancer Research, Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Glypican 3 Monoclonal Antibody. Tested in WB applications. This antibody reacts with Human.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to Human Glypican 3 aa 1-2 conjugated to keyhole limpet haemocyanin.(Peptide available as ab11376) |
| Applications | WB, IF, IP |
Target Information
| Target Symbol | GPC3 |
|---|---|
| Target Name | Glypican-3 |
| UniProt ID | P51654 |
| Function | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. |
| Involvement in Disease | Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1); also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. |
| Sequence Similarities | Belongs to the glypican family. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
