Anti-HDAC1 Rabbit Monoclonal Antibody (RMAB-0251486)
Cat. No.: RMAB-0251486
Category: Primary Antibodies
Research Area: Cardiovascular, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-HDAC1 Rabbit Monoclonal Antibody. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide corresponding to Human HDAC1 aa 45 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. |
| Applications | WB, IHC |
Target Information
| Target Symbol | HDAC1 |
|---|---|
| Target Name | Histone deacetylase 1 |
| UniProt ID | Q13547 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-31' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. |
| Post-translational Modifications | Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1. Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Ubiquitinated by CHFR, leading to its degradation by the proteasome. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
