Anti-HDAC2 Antibody (RMAB-0250683)
Cat. No.: RMAB-0250683
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to HDAC2
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 3F3 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide corresponding to Human HDAC2 aa 45-55. |
| Applications | Flow Cyt (Intra), WB, ICC/IF |
| Key Features | Mouse monoclonal to HDAC2; Suitable for: Flow Cyt (Intra), WB, ICC/IF; Knockout validated; Reacts with: Mouse, Human; Isotype: IgG1 |
Target Information
| Target Symbol | HDAC2 |
|---|---|
| Target Name | Histone deacetylase 2 |
| UniProt ID | Q92769 |
| Cellular Localization | Nucleus. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. |
| Post-translational Modifications | S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.02% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
