Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody (RMAB-0251490)
Cat. No.: RMAB-0251490
Category: Primary Antibodies
Research Area: Cardiovascular, Stem Cells, Epigenetics
INQUIRY
100 μL
Customer Size
Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody. Tested in ChIP, IP, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide corresponding to Human HDAC2 aa 45 to the C-terminus |
| Applications | WB, IHC, IP |
Target Information
| Target Symbol | HDAC2 |
|---|---|
| Target Name | Histone deacetylase 2 |
| UniProt ID | Q92769 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. |
| Post-translational Modifications | S-nitrosylated by GAPDH. In neurons, S-Nitrosylation at Cys-262 and Cys-274 does not affect the enzyme activity but abolishes chromatin-binding, leading to increases acetylation of histones and activate genes that are associated with neuronal development. In embryonic cortical neurons, S-Nitrosylation regulates dendritic growth and branching. |
| Sequence Similarities | Belongs to the histone deacetylase family. HD type 1 subfamily. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
