Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody (RMAB-0250697)
Cat. No.: RMAB-0250697
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | WB, IF, ICC |
| Key Features | Bio Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human. |
Target Information
| Target Symbol | HDAC4 |
|---|---|
| Target Name | Histone deacetylase 4 |
| UniProt ID | P56524 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. |
| Involvement in Disease | Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR). A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
