Anti-Human AITRL Polyclonal Antibody (RMAB-0251535)
Cat. No.: RMAB-0251535
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Recombinant Human AITRL |
Target Information
| Target Symbol | AITRL |
|---|---|
| Target Name | Tumor necrosis factor ligand superfamily member 18 |
| UniProt ID | Q9UNG2 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). |
| Sequence Similarities | Belongs to the tumor necrosis factor family. |
For research use only. Not for clinical use.
