Anti-Human CD5 Antibody (RMAB-0252007)
Cat. No.: RMAB-0252007
Category: Primary Antibodies
Research Area: Immunology, Stem Cell Biology
INQUIRY
100 μg
Customer Size
The UCHT2 antibody reacts with CD5, an ~67 kDa single-chain type I glycoprotein and member of the scavenger receptor superfamily, which is constitutively expressed on thymocytes, T cells, B cell subsets, peripheral blood dendritic cells and some leukemia and lymphoma cells, including chronic B lymphocytic leukemia (B-CLL) cells. CD5 is expressed at low levels on thymocytes and at high density on mature T cells. Putative ligands include CD5L and CD72. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T cell/B cell interactions via its physical and functional associations with the T cell receptor/CD3 complex and the B cell receptor. Studies with CD5 knockout mice indicate that CD5 negatively regulates antigen receptor-mediated signaling in thymocytes and mature T cells. The UCHT2 antibody binds to epitope 2 located in the extracellular domain of CD5.
Product Features
| Isotype | IgG1, kappa |
|---|---|
| Host Species | Mouse |
| Clone Number | UCHT2 |
| Conjugate | APC, Biotin, FITC, PE, PerCP-Cyanine55, Unconjugated |
| Species Reactivity | Capuchin Monkey, Chimpanzee, Common Marmoset, Cynomolgus, Human, Owl Monkey, Rhesus |
| Applications | Flow Cyt, ICC, IHC, WB |
| Key Features | APC, Biotin, FITC, PE, PerCP-Cyanine5.5, Unconjugated |
Target Information
| Target Symbol | CD5 |
|---|---|
| Target Name | T-cell surface glycoprotein CD5 |
For research use only. Not for clinical use.
