Anti-Human IL-11 Monoclonal Antibody (RMAB-0251691)
Cat. No.: RMAB-0251691
Category: Primary Antibodies
INQUIRY
500 μg
Customer Size
Product Features
| Clonality | Monoclonal |
|---|---|
| Host Species | Mouse |
| Immunogen | E.coli derived Recombinant Human IL-11 |
Target Information
| Target Symbol | IL11 |
|---|---|
| Target Name | Interleukin-11 |
| UniProt ID | P20809 |
| Cellular Localization | Secreted. |
| Function | Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:1291966). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:3279168). |
| Sequence Similarities | Belongs to the IL-6 superfamily. |
For research use only. Not for clinical use.
