Anti-Human IL-3 Monoclonal Antibody (RMAB-0251648)
Cat. No.: RMAB-0251648
Category: Primary Antibodies
INQUIRY
500 μg
Customer Size
Product Features
| Clonality | Monoclonal |
|---|---|
| Host Species | Mouse |
| Immunogen | E.coli derived Recombinant Human IL-3 |
Target Information
| Target Symbol | IL3 |
|---|---|
| Target Name | Interleukin-3 |
| UniProt ID | P08700 |
| Cellular Localization | Secreted. |
| Function | Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:1779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234). |
| Sequence Similarities | Belongs to the IL-3 family. |
For research use only. Not for clinical use.
