Anti-Human IL-7 Polyclonal Antibody (RMAB-0251676)
Cat. No.: RMAB-0251676
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Recombinant Human IL-7 |
Target Information
| Target Symbol | IL7 |
|---|---|
| Target Name | Interleukin-7 |
| UniProt ID | P13232 |
| Cellular Localization | Secreted. |
| Function | Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:7527823, PubMed:2587237). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:2974963). |
| Involvement in Disease | Epidermodysplasia verruciformis 5 (EV5): A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive. The disease may be caused by variants affecting the gene represented in this entry. |
| Sequence Similarities | Belongs to the IL-7/IL-9 family. |
For research use only. Not for clinical use.
