Anti-Human IL-8 Monoclonal Antibody (RMAB-0251885)
Cat. No.: RMAB-0251885
Category: Primary Antibodies
INQUIRY
500 μg
Customer Size
Product Features
| Clonality | Monoclonal |
|---|---|
| Host Species | Mouse |
| Immunogen | E.coli derived Recombinant Human IL-8 (CXCL8) (72 a.a.) |
Target Information
| Target Symbol | IL8 |
|---|---|
| Target Name | Interleukin-8 |
| UniProt ID | P10145 |
| Cellular Localization | Secreted. |
| Function | Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:763628, PubMed:18692776). Also plays an important role in neutrophil activation (PubMed:962351, PubMed:2145175). Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells (PubMed:18471, PubMed:1891716). G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways (PubMed:8662698, PubMed:119713). |
| Post-translational Modifications | Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. (Microbial infection) Cleaved by group A Streptococcus protease SpyCEP; leading to impaired neutrophil endothelial transmigration and thus increased virulence. |
| Sequence Similarities | Belongs to the intercrine alpha (chemokine CxC) family. |
For research use only. Not for clinical use.
