Anti-Human TPO Polyclonal Antibody (RMAB-0251789)
Cat. No.: RMAB-0251789
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli derived Animal-Free Recombinant Human TPO |
Target Information
| Target Symbol | TPO |
|---|---|
| Target Name | Thyroid peroxidase |
| UniProt ID | P07202 |
| Cellular Localization | Membrane; Single-pass type I membrane protein.: Cell surface. |
| Function | Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). |
| Involvement in Disease | An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Thyroid dyshormonogenesis 2A (TDH2A): A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. The disease is caused by variants affecting the gene represented in this entry. |
| Post-translational Modifications | Glycosylated. Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface. Cleaved in its N-terminal part. |
| Sequence Similarities | Belongs to the peroxidase family. XPO subfamily. |
For research use only. Not for clinical use.
