Anti-IFNGR1 Antibody (RMAB-0250738)
Cat. No.: RMAB-0250738
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to IFNGR1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR24127-89 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Mouse |
| Immunogen | Recombinant fragment. |
| Applications | ICC/IF, WB, Flow Cyt, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to IFNGR1; Suitable for: ICC/IF, WB, Flow Cyt, IP; Reacts with: Mouse |
Target Information
| Target Symbol | IFNGR1 |
|---|---|
| Target Name | Interferon gamma receptor 1 |
| UniProt ID | P15260 |
| Cellular Localization | Membrane. |
| Function | Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. |
| Involvement in Disease | Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 5% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. |
| Post-translational Modifications | Phosphorylated at Ser/Thr residues. |
| Sequence Similarities | Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Storage & Shipping
| Storage Buffer | Preservative: 0.01% Sodium azide; Constituents: 59.94% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
