Anti-Integrin alpha 6 Antibody (RMAB-0250758)
Cat. No.: RMAB-0250758
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Integrin alpha 6
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR5578 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human Integrin alpha 6 aa 1-2. The exact sequence is proprietary. |
| Applications | WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Integrin alpha 6; Suitable for: WB; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | ITGA6 |
|---|---|
| Target Name | Integrin alpha-6 |
| UniProt ID | P23229 |
| Cellular Localization | Cell membrane. Cell membrane. |
| Function | Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:2682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:2235176). |
| Involvement in Disease | Epidermolysis bullosa letalis, with pyloric atresia |
| Post-translational Modifications | Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-113' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand. In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro. Palmitoylation by DHHC3 enhances stability and cell surface expression. |
| Sequence Similarities | Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
