Anti-LAMP2 Antibody (RMAB-0250809)
Cat. No.: RMAB-0250809
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rat monoclonal to LAMP2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rat |
| Clone Number | GL2A7 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Mouse, Rabbit, Human |
| Immunogen | Tissue, cells or virus corresponding to Mouse LAMP2. Purified preparation of mouse liver lysosomal membranes. |
| Applications | IHC-Fr, ICC, ICC/IF, IHC-FoFr, IP, Flow Cyt, WB, IHC-P |
| Key Features | Rat monoclonal to LAMP2; Suitable for: IHC-Fr, ICC, ICC/IF, IHC-FoFr, IP, Flow Cyt, WB, IHC-P; Reacts with: Mouse, Rabbit, Human; Isotype: IgG |
Target Information
| Target Symbol | LAMP2 |
|---|---|
| Target Name | Lysosome-associated membrane glycoprotein 2 |
| UniProt ID | P13473 |
| Cellular Localization | Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| Function | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. |
| Involvement in Disease | Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. |
| Post-translational Modifications | O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. |
| Sequence Similarities | Belongs to the LAMP family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.09% Sodium azide; Constituents: PBS, 50% Glycerol |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
