Anti-LAMP2 Antibody - Lysosome Marker (RMAB-0250810)
Cat. No.: RMAB-0250810
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to LAMP2 - Lysosome Marker
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | H4B4 |
| Form | Liquid |
| Purity | Affinity purified |
| Species Reactivity | Human, Rhesus monkey, African green monkey |
| Immunogen | Tissue, cells or virus corresponding to Human LAMP2. Human adherent peripheral blood cells |
| Applications | ICC, ICC/IF, IHC-Fr, WB, IHC-FoFr, Flow Cyt (Intra), IHC-P |
| Key Features | Mouse monoclonal to LAMP2 - Lysosome Marker; Suitable for: ICC, ICC/IF, IHC-Fr, WB, IHC-FoFr, Flow Cyt (Intra), IHC-P; Reacts with: Human, Rhesus monkey, African green monkey; Isotype: IgG1 |
Target Information
| Target Symbol | LAMP2 |
|---|---|
| Target Name | Lysosome-associated membrane glycoprotein 2 |
| UniProt ID | P13473 |
| Cellular Localization | Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| Function | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. |
| Involvement in Disease | Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. |
| Post-translational Modifications | O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. |
| Sequence Similarities | Belongs to the LAMP family. |
Storage & Shipping
| Storage Buffer | pH: 8.20; Constituent: 100% Borate buffered saline |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
