Anti-Lipoprotein lipase Antibody (RMAB-0250818)
Cat. No.: RMAB-0250818
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Mouse monoclonal to Lipoprotein lipase
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | 5D2 |
| Form | Liquid |
| Purity | Protein G purified |
| Species Reactivity | Mouse, Cat, Human |
| Immunogen | Full length native protein (purified) corresponding to Cow Lipoprotein lipase. Purified bovine milk lipoprotein lipase protein. |
| Applications | ICC/IF, Flow Cyt |
| Key Features | Mouse monoclonal to Lipoprotein lipase; Suitable for: ICC/IF, Flow Cyt; Knockout validated; Reacts with: Mouse, Cat, Human; Isotype: IgG1 |
Target Information
| Target Symbol | LPL |
|---|---|
| Target Name | Lipoprotein lipase |
| UniProt ID | P06858 |
| Cellular Localization | Cell membrane. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles. |
| Function | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. |
| Involvement in Disease | Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. |
| Post-translational Modifications | Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. |
| Sequence Similarities | Belongs to the This antibody hydrolase superfamily. Lipase family. Contains 1 PLAT domain. |
Storage & Shipping
| Storage Buffer | Preservative: 0.1% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
