Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody (RMAB-0250820)
Cat. No.: RMAB-0250820
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human |
| Applications | WB, IHC |
| Key Features | Bio Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody. Tested in IHC, WB applications. This antibody reacts with Human. |
Target Information
| Target Symbol | LPL |
|---|---|
| Target Name | Lipoprotein lipase |
| UniProt ID | P06858 |
| Function | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. |
| Involvement in Disease | Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
