Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody

Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody (RMAB-0251493)

Cat. No.: RMAB-0251493

Category: Primary Antibodies

Research Area: Stem Cells

INQUIRY 100 μL Customer Size

Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Isotype	IgG
Clonality	Monoclonal
Host Species	Rabbit
Form	Liquid
Species Reactivity	Human
Immunogen	Full length native protein (purified) corresponding to Cow Lipoprotein lipase. Purified bovine milk lipoprotein lipase protein.
Applications	WB, Flow Cyt, IHC, IF, ICC, IP

Target Symbol	LPL
Target Name	Lipoprotein lipase
UniProt ID	P06858
Function	The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
Involvement in Disease	Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
Post-translational Modifications	Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
Sequence Similarities	Belongs to the This antibody hydrolase superfamily. Lipase family. Contains 1 PLAT domain.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.