Anti-MEF2A+MEF2C Rabbit Monoclonal Antibody (RMAB-0250852)
Cat. No.: RMAB-0250852
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Applications | WB, Flow Cyt, IHC, IF, ICC |
| Key Features | Bio Anti-MEF2A+MEF2C Rabbit Monoclonal Antibody. Tested in IF, WB applications. This antibody reacts with Human, Mouse, Rat. |
Target Information
| Target Symbol | MEF2C |
|---|---|
| Target Name | Myocyte-specific enhancer factor 2C |
| UniProt ID | Q06413 |
| Developmental Stage | Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease. |
| Function | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. |
| Involvement in Disease | Defects in MEF2C are the cause of mental retardation-stereotypic movements-epilepsy and/or cerebral malformations (MRSME). It is a disorder characterized by severe mental retardation, absent speech, hypotonia, poor eye contact and stereotypic movements. Dysmorphic features include high broad forehead with variable small chin, short nose with anteverted nares, large open mouth, upslanted palpebral fissures and prominent eyebrows. Some patients have seizures. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
