Anti-Mib1/Mindbomb Antibody (RMAB-0250858)
Cat. No.: RMAB-0250858
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to Mib1/Mindbomb
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR2762(2) |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide within Human Mib1/Mindbomb aa 1-1 (N terminal). The exact sequence is proprietary. |
| Applications | WB, IHC-P, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Mib1/Mindbomb; Suitable for: WB, IHC-P, ICC/IF; Reacts with: Mouse, Human |
Target Information
| Target Symbol | MIB1 |
|---|---|
| Target Name | E3 ubiquitin-protein ligase MIB1 |
| UniProt ID | Q86YT6 |
| Cellular Localization | Cytoplasm. Cell membrane. Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. |
| Post-translational Modifications | Ubiquitinated. Possibly via autoubiquitination. |
| Sequence Similarities | Contains 9 ANK repeats. Contains 2 MIB/HERC2 domains. Contains 3 RING-type zinc fingers. Contains 1 ZZ-type zinc finger. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
