Anti-Murine IL-18BP Polyclonal Antibody (RMAB-0251905)
Cat. No.: RMAB-0251905
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Goat |
| Immunogen | E.coli derived Recombinant Murine IL-18BP |
Target Information
| Target Symbol | IL18BP |
|---|---|
| Target Name | Interleukin-18-binding protein |
| UniProt ID | O95998 |
| Cellular Localization | Secreted. |
| Function | Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. |
| Involvement in Disease | Hepatitis, fulminant viral (FVH): An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms. Disease susceptibility may be associated with variants affecting the gene represented in this entry. |
| Post-translational Modifications | N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-13: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4. |
For research use only. Not for clinical use.
