Anti-Nanog Rabbit Monoclonal Antibody

Anti-Nanog Rabbit Monoclonal Antibody (RMAB-0251471)

Cat. No.: RMAB-0251471

Category: Primary Antibodies

Research Area: Cancer Research, Stem Cells, Epigenetics

INQUIRY 100 μL Customer Size

Anti-Nanog Rabbit Monoclonal Antibody. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human.

Target Symbol	NANOG
Target Name	Homeobox protein NANOG
UniProt ID	Q9H9S0
Developmental Stage	Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.
Function	Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.
Sequence Similarities	Belongs to the Nanog homeobox family. Contains 1 homeobox DNA-binding domain.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.