Anti-Nestin Antibody (RMAB-0250900)
Cat. No.: RMAB-0250900
Category: Primary Antibodies
INQUIRY
100 μL
1 mL
Rabbit monoclonal to Nestin
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | SP103 |
| Form | Liquid |
| Purity | Protein A/G purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human Nestin aa 16 to the C-terminus (C terminal). The exact sequence is proprietary. |
| Applications | ICC/IF, IHC-Fr, WB, IHC-P, Flow Cyt (Intra) |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Nestin; Suitable for: ICC/IF, IHC-Fr, WB, IHC-P, Flow Cyt (Intra); Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | NES |
|---|---|
| Target Name | Nestin |
| UniProt ID | P48681 |
| Developmental Stage | Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments. |
| Function | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. |
| Post-translational Modifications | Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | pH: 7.60; Preservative: 0.1% Sodium azide; Constituents: PBS, 1% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
