Anti-Neurofilament Antibody (RMAB-0250903)
Cat. No.: RMAB-0250903
Category: Primary Antibodies
INQUIRY
50 μL
Customer Size
Mouse monoclonal to Neurofilament
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | RNF406 |
| Form | Liquid |
| Species Reactivity | Human |
| Immunogen | Neurofilament preparation of calf brain tissue. |
| Applications | WB, IHC-P |
| Key Features | Mouse monoclonal to Neurofilament; Suitable for: WB, IHC-P; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | NEFM |
|---|---|
| Target Name | Neurofilament medium polypeptide |
| UniProt ID | P07197 |
| Function | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. |
| Post-translational Modifications | There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization. |
| Sequence Similarities | Belongs to the intermediate filament family. |
Storage & Shipping
| Storage Buffer | Preservative: 0.09% Sodium azide; Constituent: 99% PBS |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. |
For research use only. Not for clinical use.
