Anti-Nkx2.5 Antibody (RMAB-0250911)
Cat. No.: RMAB-0250911
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Nkx2.5
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20168 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Nkx2.5; Suitable for: WB; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | NKX2-5 |
|---|---|
| Target Name | Homeobox protein Nkx-2.5 |
| UniProt ID | P52952 |
| Cellular Localization | Nucleus. |
| Function | Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development. |
| Involvement in Disease | Atrial septal defect 7, with or without atrioventricular conduction defectsTetralogy of FallotConotruncal heart malformationsHypothyroidism, congenital, non-goitrous, 5Ventricular septal defect 3Hypoplastic left heart syndrome 2Asplenia, isolated congenital |
| Sequence Similarities | Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
