Anti-NOTCH4 Rabbit Monoclonal Antibody

Anti-NOTCH4 Rabbit Monoclonal Antibody (RMAB-0251418)

Cat. No.: RMAB-0251418

Category: Primary Antibodies

Research Area: Cardiovascular, Stem Cells, Epigenetics

INQUIRY 100 μL Customer Size

Anti-NOTCH4 Rabbit Monoclonal Antibody. Tested in WB applications. This antibody reacts with Human, Mouse.

Target Symbol	NOTCH4
Target Name	Neurogenic locus notch homolog protein 4
UniProt ID	Q99466
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.
Post-translational Modifications	Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. Phosphorylated.
Sequence Similarities	Belongs to the NOTCH family. Contains 5 ANK repeats. Contains 28 EGF-like domains. Contains 3 LNR (Lin/Notch) repeats.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.