Anti-Olig2 Antibody (RMAB-0250935)
Cat. No.: RMAB-0250935
Category: Primary Antibodies
INQUIRY
10 μL
100 μL
Rabbit monoclonal to Olig2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR2673 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | ICC/IF, WB, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Olig2; Suitable for: ICC/IF, WB, IHC-P; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | OLIG2 |
|---|---|
| Target Name | Oligodendrocyte transcription factor 2 |
| UniProt ID | Q13516 |
| Cellular Localization | Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Involvement in Disease | A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14; 21)(q11.2; q22) with TCRA. |
| Domain | The bHLH is essential for interaction with NKX2-2. |
| Sequence Similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 59% PBS, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
