Anti-Otx2 Antibody (RMAB-0250943)
Cat. No.: RMAB-0250943
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Otx2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20375 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | WB, IHC-P, IP |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Otx2; Suitable for: WB, IHC-P, IP; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | OTX2 |
|---|---|
| Target Name | Homeobox protein OTX2 |
| UniProt ID | P32243 |
| Cellular Localization | Nucleus. |
| Developmental Stage | Embryo. |
| Function | Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Involvement in Disease | Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 8% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures. |
| Sequence Similarities | Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 0.05% BSA, 40% Glycerol |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
