Anti-PEG10/EDR Antibody (RMAB-0250965)
Cat. No.: RMAB-0250965
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to PEG10/EDR
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR20051 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | Flow Cyt (Intra), ICC/IF, IP, IHC-P, WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to PEG10/EDR; Suitable for: Flow Cyt (Intra), ICC/IF, IP, IHC-P, WB; Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | PEG10 |
|---|---|
| Target Name | Retrotransposon-derived protein PEG10 |
| UniProt ID | Q86TG7 |
| Cellular Localization | Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the HepG2 cell line. Colocalized with ALK1. |
| Developmental Stage | Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation. |
| Function | Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. |
| Post-translational Modifications | Isoform RF1/RF2 undergoes proteolytic cleavage. |
| Sequence Similarities | Contains 1 CCHC-type zinc finger. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
