Anti-PIM1 Antibody (RMAB-0250982)
Cat. No.: RMAB-0250982
Category: Primary Antibodies
INQUIRY
50 μg
100 μg
Mouse monoclonal to PIM1
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | ZP003 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide derived from the internal region of the human PIM1 protein, which is 94% and 88% homologous with rat and mouse, respectively. |
| Applications | WB |
| Key Features | Mouse monoclonal to PIM1; Suitable for: WB; Knockout validated; Reacts with: Human; Isotype: IgG1 |
Target Information
| Target Symbol | PIM1 |
|---|---|
| Target Name | Serine/threonine-protein kinase pim-1 |
| UniProt ID | P11309 |
| Cellular Localization | Cytoplasm. Nucleus and Cell membrane. |
| Function | May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis. |
| Post-translational Modifications | Autophosphorylated on both serine/threonine and tyrosine residues. |
| Sequence Similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. Contains 1 protein kinase domain. |
Storage & Shipping
| Storage Buffer | pH: 7.40; Preservative: 0.1% Sodium azide; Constituent: PBS |
|---|---|
| Storage & Shipping | Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
