Anti-PIM1 Rabbit Monoclonal Antibody (RMAB-0250983)
Cat. No.: RMAB-0250983
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ICC |
| Key Features | Bio Anti-PIM1 Rabbit Monoclonal Antibody. Tested in IF, IHC, WB applications. This antibody reacts with Human, Mouse. |
Target Information
| Target Symbol | PIM1 |
|---|---|
| Target Name | Serine/threonine-protein kinase pim-1 |
| UniProt ID | P11309 |
| Function | May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis. |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
