Anti-PTCH2 Antibody (RMAB-0250998)
Cat. No.: RMAB-0250998
Category: Primary Antibodies
INQUIRY
100 μL
10 µL
Rabbit monoclonal to PTCH2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR26073-39 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide. |
| Applications | Flow Cyt (Intra), IP, IHC-P, WB, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to PTCH2; Suitable for: Flow Cyt (Intra), IP, IHC-P, WB, ICC/IF; Reacts with: Human |
Target Information
| Target Symbol | PTCH2 |
|---|---|
| Target Name | Protein patched homolog 2 |
| UniProt ID | Q9Y6C5 |
| Cellular Localization | Membrane. |
| Function | May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). |
| Involvement in Disease | Defects in PTCH2 are a cause of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome).Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC). |
| Sequence Similarities | Belongs to the patched family. Contains 1 SSD (sterol-sensing) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
