Anti-Pumilio 2 Antibody (RMAB-0251000)
Cat. No.: RMAB-0251000
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Pumilio 2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR3813 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human Pumilio 2 aa 1-1. The exact sequence is proprietary. |
| Applications | Flow Cyt (Intra), WB, IP, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Pumilio 2; Suitable for: Flow Cyt (Intra), WB, IP, ICC/IF; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | PUM2 |
|---|---|
| Target Name | Pumilio homolog 2 |
| UniProt ID | Q8TB72 |
| Cellular Localization | Cytoplasm. Cytoplasmic granule. Cytoplasm > perinuclear region. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. |
| Function | Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts. |
| Domain | The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs. |
| Sequence Similarities | Contains 1 PUM-HD domain. Contains 8 pumilio repeats. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
