Anti-RBPJK Antibody (RMAB-0251003)
Cat. No.: RMAB-0251003
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to RBPJK
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR13479 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide. |
| Applications | Flow Cyt (Intra), WB, ICC/IF |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to RBPJK; Suitable for: Flow Cyt (Intra), WB, ICC/IF; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | RBPJ |
|---|---|
| Target Name | Recombining binding protein suppressor of hairless |
| UniProt ID | Q06330 |
| Cellular Localization | Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway. |
| Function | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. |
| Sequence Similarities | Belongs to the Su(H) family. Contains 1 IPT/TIG domain. |
Storage & Shipping
| Storage Buffer | Preservative: 0.01% Sodium azide; Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
