Anti-Smad1 Antibody (RMAB-0251040)
Cat. No.: RMAB-0251040
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Smad1
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR5522 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide within Human Smad1 aa 2-3. The exact sequence is proprietary. |
| Applications | WB, IHC-P, Flow Cyt (Intra) |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Smad1; Suitable for: WB, IHC-P, Flow Cyt (Intra); Knockout validated; Reacts with: Human |
Target Information
| Target Symbol | SMAD1 |
|---|---|
| Target Name | Mothers against decapentaplegic homolog 1 |
| UniProt ID | Q15797 |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane. |
| Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP3 repressor SNIP1. |
| Post-translational Modifications | Phosphorylated on serine by BMP type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. |
| Sequence Similarities | Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.
