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Anti-Smad1 Antibody (RMAB-0251040)

Cat. No.: RMAB-0251040

Category: Primary Antibodies

INQUIRY 100 μL Customer Size
Rabbit monoclonal to Smad1

Product Features

Isotype IgG
Clonality Monoclonal
Host Species Rabbit
Clone Number EPR5522
Form Liquid
Purity Protein A purified
Species Reactivity Human
Immunogen Synthetic peptide within Human Smad1 aa 2-3. The exact sequence is proprietary.
Applications WB, IHC-P, Flow Cyt (Intra)
Key Features Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Smad1; Suitable for: WB, IHC-P, Flow Cyt (Intra); Knockout validated; Reacts with: Human

Target Information

Target Symbol SMAD1
Target Name Mothers against decapentaplegic homolog 1
UniProt ID Q15797
Cellular Localization Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
Function Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP3 repressor SNIP1.
Post-translational Modifications Phosphorylated on serine by BMP type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
Sequence Similarities Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain.

Storage & Shipping

Storage Buffer pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA
Storage & Shipping Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.

For research use only. Not for clinical use.