Anti-Smad1 Antibody (RMAB-0251040)
Cat. No.: RMAB-0251040
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Smad1
Product Features
Isotype | IgG |
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Clonality | Monoclonal |
Host Species | Rabbit |
Clone Number | EPR5522 |
Form | Liquid |
Purity | Protein A purified |
Species Reactivity | Human |
Immunogen | Synthetic peptide within Human Smad1 aa 2-3. The exact sequence is proprietary. |
Applications | WB, IHC-P, Flow Cyt (Intra) |
Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Smad1; Suitable for: WB, IHC-P, Flow Cyt (Intra); Knockout validated; Reacts with: Human |
Target Information
Target Symbol | SMAD1 |
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Target Name | Mothers against decapentaplegic homolog 1 |
UniProt ID | Q15797 |
Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane. |
Function | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP3 repressor SNIP1. |
Post-translational Modifications | Phosphorylated on serine by BMP type 1 receptor kinase. Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. |
Sequence Similarities | Belongs to the dwarfin/SMAD family. Contains 1 MH1 (MAD homology 1) domain. Contains 1 MH2 (MAD homology 2) domain. |
Storage & Shipping
Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA |
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Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C. |
For research use only. Not for clinical use.