Anti-SOX2 Antibody (RMAB-0251093)
Cat. No.: RMAB-0251093
Category: Primary Antibodies
INQUIRY
100 μL
1 mL
Rabbit monoclonal to SOX2
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | SP76 |
| Form | Liquid |
| Purity | Protein A/G purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide within Human SOX2 aa 1-1 (N terminal). The exact sequence is proprietary. |
| Applications | IHC-P, ICC/IF, Flow Cyt (Intra), WB |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to SOX2; Suitable for: IHC-P, ICC/IF, Flow Cyt (Intra), WB; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | SOX2 |
|---|---|
| Target Name | Transcription factor SOX-2 |
| UniProt ID | P48431 |
| Cellular Localization | Nucleus. |
| Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP26 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Involvement in Disease | Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. |
| Post-translational Modifications | Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. |
| Sequence Similarities | Contains 1 HMG box DNA-binding domain. |
Storage & Shipping
| Storage Buffer | pH: 7.60; Preservative: 0.1% Sodium azide; Constituents: PBS, 1% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
For research use only. Not for clinical use.
