Anti-Thrombopoietin Antibody (RMAB-0251159)
Cat. No.: RMAB-0251159
Category: Primary Antibodies
INQUIRY
100 μL
Customer Size
Rabbit monoclonal to Thrombopoietin
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Clone Number | EPR14948 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human |
| Immunogen | Recombinant fragment. |
| Applications | Flow Cyt (Intra), WB, ICC/IF, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to Thrombopoietin; Suitable for: Flow Cyt (Intra), WB, ICC/IF, IHC-P; Reacts with: Human |
Target Information
| Target Symbol | THPO |
|---|---|
| Target Name | Thrombopoietin |
| UniProt ID | P40225 |
| Cellular Localization | Secreted. |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Involvement in Disease | Defects in THPO are a cause of essential thrombocythemia (ET). ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. |
| Domain | Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal. |
| Sequence Similarities | Belongs to the EPO/TPO family. |
Storage & Shipping
| Storage Buffer | pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS, 0.05% BSA |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
