Anti-Transferrin Receptor Antibody (RMAB-0251172)
Cat. No.: RMAB-0251172
Category: Primary Antibodies
INQUIRY
100 μg
Customer Size
Mouse monoclonal to Transferrin Receptor
Product Features
| Isotype | IgG1 |
|---|---|
| Clonality | Monoclonal |
| Host Species | Mouse |
| Clone Number | H68.4 |
| Form | Liquid |
| Purity | Protein A purified |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant fragment within Human Transferrin Receptor. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. |
| Applications | WB, ICC/IF, IHC-P |
| Key Features | Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Mouse monoclonal to Transferrin Receptor; Suitable for: WB, ICC/IF, IHC-P; Reacts with: Mouse, Rat, Human |
Target Information
| Target Symbol | TFRC |
|---|---|
| Target Name | Transferrin receptor protein 1 |
| UniProt ID | P02786 |
| Cellular Localization | Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:2664224).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Involvement in Disease | Immunodeficiency 46 |
| Post-translational Modifications | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-1 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
| Sequence Similarities | Belongs to the peptidase M28 family. M28B subfamily. Contains 1 PA (protease associated) domain. |
Storage & Shipping
| Storage Buffer | pH: 7.2; Preservative: 0.01% Sodium azide; Constituents: PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
|---|---|
| Storage & Shipping | Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
For research use only. Not for clinical use.
