Anti-Transferrin Receptor (CD71) TFRC Rabbit Monoclonal Antibody (RMAB-0251505)
Cat. No.: RMAB-0251505
Category: Primary Antibodies
Research Area: Stem Cells
INQUIRY
100 μL
Customer Size
Anti-Transferrin Receptor (CD71) TFRC Rabbit Monoclonal Antibody. Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Features
| Isotype | IgG |
|---|---|
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Form | Liquid |
| Species Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ICC, IP |
Target Information
| Target Symbol | TFRC |
|---|---|
| Target Name | Transferrin receptor protein 1 |
| UniProt ID | P02786 |
| Function | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:2664224).(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Involvement in Disease | Immunodeficiency 46 |
Storage & Shipping
| Storage Buffer | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
|---|---|
| Storage & Shipping | Dry Ice |
For research use only. Not for clinical use.
