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Anti-VEGF Receptor 2 Antibody (RMAB-0251181)

Cat. No.: RMAB-0251181

Category: Primary Antibodies

INQUIRY 100 μL 10 µL
Rabbit monoclonal to VEGF Receptor 2

Product Features

Isotype IgG1
Clonality Monoclonal
Host Species Rabbit
Clone Number EPR21233
Form Liquid
Purity Protein A purified
Species Reactivity Human
Immunogen Recombinant fragment.
Applications Flow Cyt, ICC/IF
Key Features Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply; Rabbit monoclonal to VEGF Receptor 2; Suitable for: Flow Cyt, ICC/IF; Reacts with: Human

Target Information

Target Symbol KDR
Target Name Vascular endothelial growth factor receptor 2
UniProt ID P35968
Cellular Localization Membrane.
Function Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Involvement in Disease Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 1% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 1% per year and replacement by fibrofatty stroma.
Post-translational Modifications Phosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-154, Tyr-159, Tyr-1175 and Tyr-1214.
Sequence Similarities Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.

Storage & Shipping

Storage Buffer pH: 7; Preservative: 0.01% Sodium azide; Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine)
Storage & Shipping Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

For research use only. Not for clinical use.