Anti-VEGF Receptor 2 KDR Rabbit Monoclonal Antibody

Anti-VEGF Receptor 2 KDR Rabbit Monoclonal Antibody (RMAB-0251363)

Cat. No.: RMAB-0251363

Category: Primary Antibodies

Research Area: Cardiovascular, Cancer Research, Stem Cells, Metabolism

INQUIRY 100 μL Customer Size

Anti-VEGF Receptor 2 KDR Rabbit Monoclonal Antibody. Tested in IP, WB applications. This antibody reacts with Human.

Target Symbol	KDR
Target Name	Vascular endothelial growth factor receptor 2
UniProt ID	P35968
Function	Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Involvement in Disease	Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 1% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 1% per year and replacement by fibrofatty stroma.
Post-translational Modifications	Phosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-154, Tyr-159, Tyr-1175 and Tyr-1214.
Sequence Similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.

Storage Buffer	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Storage & Shipping	Dry Ice

For research use only. Not for clinical use.