Atipamezole (Hydrochloride)

Atipamezole is an imidazole derivative and a selective α2-adrenergic receptor antagonist. α2-adrenergic receptor is involved in the processing of amyloid precursor protein, and is therefore a potential therapeutic target for Alzheimer's disease. Atipamezole is used to reverse the sedative and analgesic effects of dexmedetomidine, and it has also been used to assess cognitive performance of rat models in Parkinson's disease research. Reverses the sedative effects of α2-adrenergic receptor agonists in animals. Improves the efficacy of L-DOPA and apomorphine in animals with Parkinson’s disease. Enhances the turnover of serotonin and dopamine in aged rats.