Biotinylated Anti-Human BAFF Polyclonal Antibody (RMAB-0251803)
Cat. No.: RMAB-0251803
Category: Primary Antibodies
INQUIRY
25 μg
50 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Goat |
| Immunogen | E.coli derived Recombinant Human BAFF |
Target Information
| Target Symbol | BAFF |
|---|---|
| Target Name | Tumor necrosis factor ligand superfamily member 13B |
| UniProt ID | Q9Y275 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein.: Secreted. |
| Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p5 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
| Post-translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
| Sequence Similarities | Belongs to the tumor necrosis factor family. |
For research use only. Not for clinical use.
