Biotinylated Anti-Human Wnt-1 Polyclonal Antibody (RMAB-0251796)
Cat. No.: RMAB-0251796
Category: Primary Antibodies
INQUIRY
25 μg
50 μg
Product Features
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Immunogen | E.coli-derived, 38.4 kDa Recombinant Human Wnt-1 |
Target Information
| Target Symbol | Wnt1 |
|---|---|
| Target Name | Proto-oncogene Wnt-1 |
| UniProt ID | P04628 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. Secreted. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:2349939, PubMed:269272, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:2349939, PubMed:23656646). |
| Involvement in Disease | Osteoporosis (OSTEOP): A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. Disease susceptibility is associated with variants affecting the gene represented in this entry. Osteogenesis imperfecta 15 (OI15): An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients. The disease is caused by variants affecting the gene represented in this entry. |
| Post-translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity). |
| Sequence Similarities | Belongs to the Wnt family. |
For research use only. Not for clinical use.
