Celastrol

Celastrol is a topoisomerase II inhibitor. It improves memory, learning, and psychomotor activity performance when administered in rats and may have therapeutic potential for treating neurodegenerative disorders such as Alzheimer's disease. In addition, celastrol suppresses TNF-α-induced NF-κB activation and increases TNF-induced apoptosis in chronic myelogenous leukemia cells. Induces apoptosis in human leukemia cells. Activates mitophagy and inhibits dopaminergic neuronal apoptosis in mice.