Chicken Casein kinase II subunit beta(CSNK2B) ELISA Kit (RMEK-0151034)
Cat. No.: RMEK-0151034
Category: ELISA Kits
INQUIRY
1 x 96 tests
This ELISA kit is a 1. 5 hour solid-phase ELISA designed for the quantitative determination of the targets. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Features
| Species Reactivity | Chicken |
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| Assay Time | 1.5 h |
Target Information
| Target Symbol | CSNK2B |
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| UniProt ID | P67870 |
| Function | Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling (By similarity). (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML. Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcrition. |
| Cellular Localization | Nucleus. |
| Domain | The KSSR motif is part of a protein interaction pocket that mediates interaction with cellular and viral proteins. |
| Post-transcriptional Modifications | Phosphorylated by alpha subunit. |
| Involvement in Disease | Poirier-Bienvenu neurodevelopmental syndrome (POBINDS): An autosomal dominant neurodevelopmental disorder characterized by onset of seizures in infancy, developmental delay, impaired intellectual development, and poor or absent speech. The disease is caused by variants affecting the gene represented in this entry. |
Storage & Shipping
| Storage | Store at 2-8°C |
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| Shipping | Gel Packs |
| Stability | The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. |
For research use only. Not for clinical use.
