Choroid Plexus Organoid Differentiation Kit (RMMS-00560268)
Cat. No.: RMMS-00560268
Category: Cell Differentiation Kits
Research Area: Disease Modeling, Drug Discovery and Toxicity Testing, Epithelial Cell Biology, Extracellular Vesicle Research, Neuroscience, Organoids
INQUIRY
1 Kit
Culture medium kit for establishment of organoid models containing human pluripotent stem cell-derived choroid plexus-like epithelium
Product Features
| Cell Type | Epithelial Cells, PSC-Derived, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells |
|---|---|
| Formulation | Serum-Free |
| Species | Human |
| Applications | Cell Culture, Differentiation, Functional Assay, Organoid Culture, Phenotyping, Toxicity Assay |
| Description | Take an in vitro approach to human neural biomarker discovery and central nervous system (CNS) permeability with human pluripotent stem cell (hPSC)-derived organoids patterned to the choroid plexus, the specialized brain epithelium that forms the blood-cerebrospinal fluid barrier. With a three-dimensional tissue structure and functional barrier epithelium, you’ll achieve unprecedented access and control in studying CNS permeability for drug distribution studies, as well as for production and extraction of cerebrospinal fluid (CSF). Using Choroid Plexus Differentiation Kit’s simple five-stage protocol, you can efficiently and reproducibly generate choroid plexus organoids for a variety of downstream applications. Choroid plexus organoid formation is initiated through an intermediate embryoid body (EB) formation step followed by expansion of neuroepithelia and patterning to choroid plexus-like epithelium. After a maturation period, organoids generated using this kit feature cystic structures filled with a fluid resembling CSF and surrounded by an epithelial layer expressing ependymal choroid plexus-specific markers (TTR, CLIC6, AQP1). For extended periods of organoid culture (> 40 days), the components required for organoid maturation can be purchased as Choroid Plexus Organoid Maturation Kit. |
Storage & Shipping
| Storage | -20°C or colder |
|---|---|
| Shipping | Shipped on gel packs. |
For research use only. Not for clinical use.
