Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (RMML-00120962)
Cat. No.: RMML-00120962
Category: Inhibitors & Activators
INQUIRY
10 mg
50 mg
Stable, cell-permeable analog of pifithrin-α. p53 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Stable, cell-permeable analog of pifithrin-α. p53 inhibitor; CAS Number: 511296-88-1; Purity: > 98%; Soluble in ethanol to 25 mM and in DMSO to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Biological Description | Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro.See similar compound |
|---|---|
| CAS Number | 511296-88-1 |
| Chemical Name | 2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide |
| SMILES | CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br |
| Molecular Formula | C16H16N2S.HBr |
| Molecular Weight | 348.28 Da |
| PubChem Identifier | 11515812 |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in ethanol to 25 mM and in DMSO to 100 mM |
| Storage & Shipping | Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
For research use only. Not for clinical use.
