GANT 61, GLI1 and 2 inhibitor (RMML-00120921)
Cat. No.: RMML-00120921
Category: Inhibitors & Activators
INQUIRY
50 mg
10 mg
Selective GLI1 and 2 inhibitor
Product Features
| Source | Synthetic |
|---|---|
| Purity | > 98% |
| Key Features | Selective GLI1 and 2 inhibitor; CAS Number: 500579-04-4; Purity: > 98%; Soluble in DMSO to 50 mM and in ethanol to 100 mM; Form / State: Solid; Source: Synthetic |
Compound Information
| Target Pathways | GLI1 and 2 |
|---|---|
| Biological Description | Selective GLI1 and 2 inhibitor (IC50 = 5 μM). Blocks the hedgehog/smoothened signaling pathway. Anticancer activity in vitro and in vivo. |
| Alternative Names | NSC 136476 |
| CAS Number | 500579-04-4 |
| Chemical Name | 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis(N,N-dimethylbenzenamine) |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(CC3=CC=CC=C3N(C)C)C2C4=CC=NC=C4 |
| Molecular Formula | C27H35N5 |
| Molecular Weight | 429.61 Da |
Storage & Shipping
| Handling | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
|---|---|
| Solubility | Soluble in DMSO to 50 mM and in ethanol to 100 mM |
| Storage & Shipping | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
For research use only. Not for clinical use.
